Dead space ventilation slideshare8/26/2023 Vasodilation or vasoconstriction, caused by disease or anesthetic drugs, enhances V/Q mismatching and hypoxemia. Both ventilation and perfusion increase toward the dependent regions of the lung, but since blood is heavier than lung parenchyma, perfusion increases at a faster rate than ventilation. In the normal lung, ventilation (V) and perfusion (Q) are not evenly matched (known as V/Q mismatch), and this worsens with lung disease and dorsal or lateral recumbencies. It does no good to ventilate an alveolus that is not being perfused ( alveolar dead space) or to perfuse an alveolus that is not being ventilated because of atelectasis (collapse of alveoli). ![]() The “matching” of ventilation and perfusion is important to proper lung function.
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